Endocrine Abstracts

Introduction: Melatonin is involved in many physiological processes, including the regulation of circadian rhythms, sleep, antioxidant effect, aging, tumor growth, reproduction and bone formation. The latter function is also regulated by the metabolism of vitamin D. Our goal during this study is to detect a possible increase in vitamin D levels under the effect of exogenous melatonin.Participants and methods: Different anthropometric parameters were coll...

Introduction: Pituitary apoplexy (PA) is a rare incident defined by the occurrence of necrosis and/or haemorrhage of the pituitary gland. PA is a clinical syndrome characterized by the sudden onset of headache, vomiting, visual impairment and decreased consciousness in some cases. The objectives of our study are to describe its clinical, biological and imaging features as well as the management of PA in the region of Sfax.Patients and methods: It is a re...

IntroductionThe thresholds of late night salivary cortisol (LNSC) vary widely among studies due to differences in assay methodologies and in control groups. We aimed to verify the analytical performance of the LNSC by electrochimiluminescence assay (ECLIA) and to establish cut-off values of LNSC for the screening of Cushing’s syndrome (CS).MethodsPatients with suspected CS underwent screening tests inclu...

Introduction: Hypothalamic-pituitary-adrenal axis dysfunction (HPA) has been reported in patients with schizophrenia and bipolar disorders but findings are inconsistent and few studies have conducted direct comparaisons of HPA biomarkers in drug native patients. We aimed to assess serum and salivary cortisol in the morning in drug-naive schizophrenic patients compared to controls.Methods: This was a cross-sectional case-control study conducted between Ju...